|Non- Member||Replenish Hydration Members|
(check volume, hand volume)
(upper lip lines, thin lips)
What is the Restylane family of products, and how are Restylane® Silk, Restylane® Lyft, Restylane®, Restylane® Refyne and Restylane® Defyne different?
The Restylane family of products is a brand of hyaluronic acid dermal fillers, which includes Restylane Silk, Restylane Lyft, Restylane, Restylane Refyne and Restylane Defyne. Each is a clear gel formulation of hyaluronic acid specifically formulated to act like your body’s own naturally produced hyaluronic acid. Each Restylane product is designed for a specific purpose.
Restylane Silk is the first FDA-approved product specifically designed for subtle lip augmentation and the smoothing of wrinkles around the mouth. It is composed of a gel that is smaller and smoother than other Restylane products, resulting in a softer, more precise result — ideal for restoring and enhancing the lips. Additionally, Silk is administered via ultrafine needle, which is designed for improved accuracy and precision.
Restylane Lyft is approved by the FDA to correct volume deficit in the back of the hands, for cheek augmentation and the correction of age-related midface contour deficiencies, as well as the treatment of moderate to severe facial folds, such as the nasolabial folds (smile lines). Lyft is the first and only hyaluronic filler approved by the FDA to treat face and hands.2,3 Lyft contains 0.3% lidocaine, which is added to reduce the discomfort during treatment.
Restylane is used to add volume and fullness to the skin to correct moderate to severe facial wrinkles and folds, such as the lines from your nose to the corners of your mouth (nasolabial folds). Restylane is also indicated for lip augmentation.
Restylane Refyne integrates with your skin to help smooth out the lines that run alongside the corners of your mouth (nasolabial folds and marionette lines)4 and the flexibility you need for natural-looking movement and expressions.
Restylane Defyne is designed to act like your body’s own hyaluronic acid to help smooth out deeper lines around your mouth (nasolabial folds and marionette lines)4 while letting you look more natural through a range of facial expressions.
Restylane products are approved only for patients over the age of 21.
How long do Restylane treatments last?
With full treatment, you can see lasting results for up to 18 months in nasolabial folds with Restylane;10 up to 12 months in the cheeks, up to 6 months in the back of the hands, and up to 6 months in facial wrinkles and folds, such as nasolabial folds, with Restylane Lyft;3 6 months for lips and perioral rhytids with Restylane Silk;11 and up to 12 months in the facial wrinkles and folds (such as nasolabial folds and marionette lines) with Restylane Refyne and Restylane Defyne.
Restylane Silk: In clinical studies, the results of Restylane Silk lasted approximately 6 months following treatment. In a U.S. clinical trial involving 221 mostly female subjects, 98% of subjects reported a visible improvement in lip fullness in upper and lower lip (combined) 14 days after injection, and 77% still had lip improvement at 6 months following injection.
Restylane Lyft: In a clinical trial involving 150 subjects, blinded evaluators observed that 90% of subjects treated with Restylane Lyft showed an improvement in fullness in the right and left midface areas (combined) at 2 months, and 54% of subjects showed an improvement at 12 months. Additionally, 95% of subjects reported that they were satisfied with the appearance of their midface at 2 months, and 73% of subjects were satisfied at 12 months.3 In a clinical trial involving 89 treated subjects, blinded evaluators observed that 86% of subjects* treated with Restylane Lyft showed an improvement in volume of the back of the hands at 3 months, and 76% of subjects* showed an improvement at 6 months. Improvement was defined as subjects with a Merz Hand Grading Scale (MHGS) score of ≥1 grade from baseline by the blinded evaluator’s live assessment.
*n=85 subjects treated.
Restylane: In a clinical study treating the lines from the nose to the corners of the mouth (laugh lines), blinded evaluators reported that 95% of subjects improved for up to 18 months when they received an initial Restylane treatment, plus a follow-up treatment approximately 4.5 or 9 months later. Using this Restylane regimen of treatments, blinded evaluators reported similar subject improvement, on average, at 18 months compared to their Week 2 Wrinkle Severity Rating Scale (WSRS) score.
Restylane Refyne & Restylane Defyne: In a clinical study of subjects treated for laugh lines with Restylane Refyne and Restylane Defyne, investigators reported improvement in the appearance of wrinkles for up to 12 months in the majority of patients. Using the Wrinkle Severity Rating Scale (WSRS), a validated 5-point measure of the size and depth of the wrinkles, with grade 1 defined as absence of wrinkles and grade 5 as extremely deep and long wrinkles, investigators reported that 79% of Restylane Refyne subjects and 77% of Restylane Defyne subjects had at least a 1-grade improvement on the WSRS after 6 weeks. Subjects also performed self-assessments (SSA) of wrinkle severity, with most reporting at least a 1-grade improvement in SSA scores with Restylane Refyne and with Restylane Defyne after 6 weeks
How long does it take Restylane treatments to work?
Can I buy Restylane products online?
You can only receive Restylane products from a trained specialist. Restylane Silk, Restylane Lyft, Restylane, Restylane Refyne and Restylane Defyne are administered by a physician or qualified healthcare professional.
Who should not use Restylane products?
The Restylane family of products should not be used by people who:
Are pregnant, breastfeeding, or under 22 years of age
Have recently used drugs that thin the blood or prevent clotting
Have had previous bad allergies, particularly to microorganisms known as gram-positive bacteria
Have serious allergies to drugs that have previously required in-hospital treatment
Have bleeding disorders
Have a known allergy to lidocaine, if using Restylane Silk, Restylane lyft, Restylane, Restylane Refyne or Restylane Defyne